Astragalus polysaccharide is one of the main active components of Astragalus membranaceus, which is mainly composed of rhamnose, arabinose, xylose, mannose, galactose and glucose. It can enhance the phagocytosis and secretion of macrophages, and has the functions of regulating immunity, antiviral, anti-tumor, anti-aging, anti-oxidation, anti-radiation and anti-stress. At present, as an immune booster and antiviral drugs in livestock and poultry industry has begun to be used.
Promote animal growth
Astragalus polysaccharide contains amino acids, vitamins, trace elements and other nutrients and unknown growth factors, adding dietary feed with astragalus polysaccharide can significantly improve the digestibility of ileal amino acids, as feed additives can significantly improve the quality of poultry meat, eggs and milk and yield. It is reported that the weight gain of chicks fed with astragalus refined polysaccharide is more obvious, especially in the first week of medication and after reducing the number of medication, weight gain effect is more obvious. Astragalus polysaccharide was added into the feed of chicken, duck and goose, the ratio of feed to meat was reduced to some extent, the growth rate was significantly accelerated, the egg production rate was increased by 5.20%~7.14%, the survival rate was increased by 3% ~ 5%, the elimination mortality was reduced, the color of egg yolk and the color of egg shell were deepened.
Enhance immune function
Astragalus polysaccharide can promote the growth of thymus, spleen and bursa of animals, resist the damage of immunosuppressive agents to the immune organs or repair the damaged immune organs, and maintain the normal immune function of the body. It can also accelerate the development and improvement of cellular immune function, promote plasma cell proliferation and the formation of antibodies in the body, so that the number of antibody forming cells and the determination value of hemolysis can be significantly increased, and serum immunoglobulin IgG, IgA and IgM levels as well as T and B lymphocyte activity can be increased. In addition, APS can significantly improve the body's non-specific immunity. Studies have shown that ASTRagalus polysaccharide can increase the number of peritoneal macrophages in mice, and significantly promote the phagocytosis function of mice peritoneal macrophages. In addition, by studying the effects of APS -- P on immune function of normal and chemotherapy mice, it was found that APS -- P could effectively promote the recovery of immune system function of mice after chemotherapy and enhance the NK cell killing ability of S180 tumor-bearing mice.
Treatment of viral and neoplastic diseases
Astragalus polysaccharide has significant therapeutic effect on NCD. , researchers report in the chicken embryo fibroblast (CEF) medium, to join the 5 kinds of concentration of APS, 12 h after inoculation to cultivate NDV Ⅳ department, in the determination of 72 h after inoculation CEF activity, to evaluate the APS effects on cell proliferation and its resistance to virus infection. The results showed that 1 600 and 1200 g/mL APS could significantly promote the proliferation of CEF, and 1200 g/mL APS could significantly promote the resistance of CEF to the infection of Newcastle disease virus. In recent years, the study also found that APS can improve the body's immune function is low, caused by tumor and release endogenous factor promote immune cell activation, enhance the function of the animal in vivo antioxidant enzyme system, reduce the content of lipid peroxide, prevent peroxidation caused to damage and inhibit tumor cells, thereby reducing the incidence and mortality of MD. Astragalus polysaccharide has the ability to inhibit the growth of influenza virus and the activity of sialase. Astragalus A6 has an obvious effect on the cell membrane function of influenza virus and its influence on the adsorption and penetration of the virus into sensitive cells.
Looking forward to
APS has the characteristics of small toxic and side effects, no residue, wide biological effects and so on, and has a strong development potential. At present, there are many dosage forms in APS, including injection, tablet, powder, granule, water agent, etc. Different dosage forms can be selected according to the specific clinical situation. In the poultry industry, it is used as feed additive, immune booster, vaccine adjuvant and in combination with other therapeutic drugs. It is an ideal choice for animal disease prevention, health care and treatment, and of great significance for ensuring the quality and safety of animal products.